Quarterly report pursuant to Section 13 or 15(d)

Capital Raises (Details)

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Capital Raises (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended
Sep. 13, 2021
Feb. 16, 2021
Feb. 12, 2021
Feb. 11, 2021
Jan. 24, 2021
Mar. 31, 2022
Mar. 31, 2021
Dec. 31, 2021
Capital Raises (Textual)                
Proceeds from warrant exercises   $ 18,500 $ 27,800   $ 27,800      
Number of common shares sold under offering (in shares)       3,000,000        
Preferred stock, shares authorized (in shares)           5,000,000   5,000,000
Preferred stock, shares issued (in shares)           49,250    
Preferred stock, shares outstanding (in shares)           49,250    
Net proceeds from issuance of preferred stock and warrants $ 50,600         $ 46,906 $ 0  
Preferred stock, par value (in usd per share)           $ 0.001   $ 0.001
Warrants and rights outstanding           $ 5,600    
Warrants forfeited (in shares)           29,550,000    
Shared holders participants, percent           71.00%    
Deemed dividend for the modification related to Series 8 Preferred Stock           $ (2,600)    
Deemed contribution for the modification related to Warrants issued in connection with Series 8 Preferred Stock           $ 1,500    
Series 7 Convertible Preferred Stock                
Capital Raises (Textual)                
Mezzanine equity, convertible preferred shares, par value per share (in usd per share) $ 0.001              
Mezzanine equity, convertible preferred shares, stated value per share (in usd per share) 1,000              
Mezzanine equity, convertible preferred shares, conversion price (in usd per share) $ 1.25              
Net proceeds from issuance of preferred stock and warrants $ 50,600              
Series 7 Preferred redeemed for cash (in shares)           49,250    
Series 7 Preferred redeemed for cash           $ 49,300    
Common Stock                
Capital Raises (Textual)                
Mezzanine equity, convertible preferred shares, conversion price (in usd per share) $ 1.25              
Series 8 Convertible Preferred Stock                
Capital Raises (Textual)                
Number of common shares sold under offering (in shares)           112,778,720    
Subscription price (in usd per share)           $ 940    
Original issuance discount percentage           6.00%    
Aggregate subscription value           $ 50,000    
Preferred stock, shares authorized (in shares)           53,197.7234    
Net proceeds from issuance of preferred stock and warrants           $ 46,900    
Preferred stock, par value (in usd per share)           $ 0.001    
Preferred stock, stated value per share (in usd per share)           1,000    
Preferred stock, convertible, conversion price (in dollars per share)           $ 0.4717    
Deemed dividend for the modification related to Series 8 Preferred Stock           $ (2,627) 0  
Deemed contribution for the modification related to Warrants issued in connection with Series 8 Preferred Stock           $ 1,469 $ 0  
Purchase Warrants                
Capital Raises (Textual)                
Exercisable warrants per common share (in shares)   1 1   1      
Registered Direct Offering                
Capital Raises (Textual)                
Common stock issued in direct offering (in shares)   3,000,000 7,000,000   5,800,000      
Subscription price (in usd per share) $ 920              
Original issuance discount percentage 8.00%              
Aggregate subscription value $ 54,100              
Registered Direct Offering | Series 7 Convertible Preferred Stock                
Capital Raises (Textual)                
Number of common shares sold under offering (in shares) 58,750              
Subscription price (in usd per share) $ 920              
Original issuance discount percentage 8.00%              
Aggregate subscription value $ 54,100              
Registered Direct Offering | Common Stock                
Capital Raises (Textual)                
Number of common shares sold under offering (in shares) 47,000,000              
Warrants                
Capital Raises (Textual)                
Warrants to purchase shares of common stock after adjustment (in shares)   9,950,250 15,000,000   19,354,838      
Exercise price of warrants (in usd per share)           $ 0.001    
Percent of warrants forfeited upon redemption 75.00%              
Warrants | Series 7 Convertible Preferred Stock                
Capital Raises (Textual)                
Percent of warrants forfeited upon redemption           75.00%    
Warrants | Series 8 Convertible Preferred Stock                
Capital Raises (Textual)                
Percent of warrants forfeited upon redemption           50.00%    
Warrants | Purchase Warrants                
Capital Raises (Textual)                
Exercise price of warrants (in usd per share)   $ 2.01 $ 2.00   $ 1.55      
Offering price (in usd per share)   $ 2.01 $ 2.00   $ 1.55      
Warrants | Registered Direct Offering                
Capital Raises (Textual)                
Common stock issued in direct offering (in shares)   3,000,000 7,000,000   5,800,000      
Number of common shares sold under offering (in shares) 47,000,000              
January 2021 Pre-Funded Warrants                
Capital Raises (Textual)                
Warrants to purchase shares of common stock after adjustment (in shares)         13,554,838      
Exercise price of warrants (in usd per share)         $ 0.001      
Offering price (in usd per share)         $ 1.549      
Exercisable warrants per common share (in shares)         1      
Warrants exercisable period         5 years      
February 2021 Pre-Funded Warrants                
Capital Raises (Textual)                
Warrants to purchase shares of common stock after adjustment (in shares)     8,000,000          
Exercise price of warrants (in usd per share)     $ 0.001          
Offering price (in usd per share)     $ 1.999          
Exercisable warrants per common share (in shares)     1          
Warrants exercisable period     5 years          
Second February 2021 Pre-Funded Warrants                
Capital Raises (Textual)                
Warrants to purchase shares of common stock after adjustment (in shares)   6,950,250            
Exercise price of warrants (in usd per share)   $ 0.001            
Offering price (in usd per share)   $ 2.009            
Exercisable warrants per common share (in shares)   1            
Warrants exercisable period   5 years