Annual report pursuant to Section 13 and 15(d)

Capital Raises (Details)

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Capital Raises (Details) - USD ($)
3 Months Ended 12 Months Ended
Nov. 25, 2020
Jun. 19, 2020
Mar. 03, 2020
Aug. 12, 2019
Jan. 15, 2019
Jan. 15, 2019
Dec. 31, 2020
Dec. 31, 2020
Dec. 31, 2019
Mar. 31, 2019
Capital Raises (Textual)                    
Exercise price of warrants (in usd per share)             $ 0.001 $ 0.001   $ 149.85
Weighted average exercise price (in usd per share)             $ 70.84 $ 70.84 $ 167.88  
Proceeds from warrant exercises $ 9,200,000                  
Series 5 Convertible Preferred Stock                    
Capital Raises (Textual)                    
Preferred stock, shares outstanding (in shares)             126 126 0  
ATM                    
Capital Raises (Textual)                    
Number of common shares sold under offering (in shares)               33,416,830    
Net proceeds from ATM public offering               $ 46,100,000    
Share price (in usd per share)             $ 1.45 $ 1.45    
Commission percentage rate               4.00%    
Aggregate offering amount under ATM public offering   $ 150,000,000 $ 50,000,000         $ 48,500,000    
Series 6 Convertible Preferred Stock                    
Capital Raises (Textual)                    
Warrant exercise price per share after adjustment       $ 12.4875            
Preferred stock, shares outstanding (in shares)             0 0    
Number of common shares sold under offering (in shares)       144,387            
Preferred stock stated value (in usd per share)       $ 1,000            
Common stock issued in direct offering (in shares)                 2,997  
August 2019 Financing                    
Capital Raises (Textual)                    
Number of preferred shares sold under public offering       2,997            
Gross proceeds from offering       $ 4,800,000            
Number of warrants issued after adjustment (in shares)       384,387            
Net proceeds from ATM public offering       $ 4,000,000            
January 2019 Capital Raise                    
Capital Raises (Textual)                    
Warrants to purchase shares of common stock after adjustment         80          
Exercise price of warrants (in usd per share)         $ 149.85          
Gross proceeds from offering         $ 12,000,000          
Proceeds from issuance, initial public offering         $ 10,770,000          
Number of warrants issued after adjustment (in shares)           61,562        
Deemed dividend           $ 1,300,000        
January 2019 Capital Raise | Series 5 Convertible Preferred Stock                    
Capital Raises (Textual)                    
Preferred stock, shares outstanding (in shares)             126 126    
Series 5 Convertible Preferred Stock                    
Capital Raises (Textual)                    
Units sold in public offering (in shares)         12,000          
Number of preferred shares sold under public offering         12,000 12,000        
Preferred stock, shares outstanding (in shares)             126 126    
Common stock issued in direct offering (in shares)                 12,000  
Series 4 Convertible Preferred Stock                    
Capital Raises (Textual)                    
Warrant exercise price per share after adjustment         $ 223.20 $ 223.20        
Preferred stock, shares outstanding (in shares)             1 1    
Maxim Warrant                    
Capital Raises (Textual)                    
Aggregate offering amount   $ 150,000,000 $ 50,000,000              
Commission percentage rate   3.25% 4.00%              
2020 Pre-Funded Warrant                    
Capital Raises (Textual)                    
Warrants to purchase shares of common stock after adjustment 3,000,000                  
Offering price (in usd per share) $ 1.249                  
Weighted average exercise price (in usd per share) 0.001                  
Warrant | Purchase Warrants                    
Capital Raises (Textual)                    
Exercise price of warrants (in usd per share) 1.25                  
Offering price (in usd per share) $ 1.25                  
Warrant | Registered Direct Offering                    
Capital Raises (Textual)                    
Warrants to purchase shares of common stock after adjustment 8,000,000                  
Common stock issued in direct offering (in shares) 5,000,000                  
Common Stock                    
Capital Raises (Textual)                    
Common stock issued in direct offering (in shares)             5,000,000 33,416,830 1,615,287  
Exercise price of warrants (in usd per share)                   $ 149.85