Annual report pursuant to Section 13 and 15(d)

Capital Raises (Details)

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Capital Raises (Details) - USD ($)
$ / shares in Units, $ in Thousands
1 Months Ended 12 Months Ended
Aug. 12, 2019
Jan. 15, 2019
Feb. 20, 2018
Jan. 05, 2018
Jun. 25, 2018
Apr. 24, 2018
Dec. 31, 2019
Capital Raises (Textual)              
Units sold in public offering           10,115  
ATM [Member]              
Capital Raises (Textual)              
Public offering, description             An aggregate of 1,470,900 shares of common stock, at a weighted average price of approximately $4.42 per share resulting in net proceeds of approximately $5.9 million to us after deduction of sales commissions equal to 4.5% of the gross sales and other offering expenses. We raised total aggregate gross proceeds of approximately $6.5 million in connection with the ATM program.
Purchase price per share             $ 4.42
Number of common shares sold under offering             1,470,900
Series 6 Convertible Preferred Stock [Member]              
Capital Raises (Textual)              
Warrant exercise price per share after adjustment $ 12.4875            
Number of common shares sold under offering 144,387            
Preferred stock stated value per share $ 1,000            
Preferred stock, shares outstanding             0
August 2019 Financing [Member]              
Capital Raises (Textual)              
Number of warrants issued after adjustment 384,387            
Exercise price of warrants $ 12.4875            
Net proceeds from this offering $ 4,000            
Gross proceeds from offering $ 4,800            
Number of preferred shares sold under public offering 2,997            
August 2019 Financing [Member] | Series 6 Convertible Preferred Stock [Member]              
Capital Raises (Textual)              
Preferred stock, shares outstanding             0
January 2019 Capital Raise [Member]              
Capital Raises (Textual)              
Public offering, description   The rights offering, the conversion price of the Series 4 Convertible Preferred Stock was reduced to the floor price of $223.20, the exercise price of the warrants issued in the April 2018 public offering were also reduced to the floor price of $223.20.          
Number of warrants issued after adjustment   61,562          
Exercise price of warrants   $ 149.85          
Net proceeds from this offering   $ 10,770          
Warrants to purchase shares of common stock after adjustment   80          
Gross proceeds from offering   $ 12,000          
Deemed dividend   $ 1,300          
January 2019 Capital Raise [Member] | Series 5 Convertible Preferred Stock [Member]              
Capital Raises (Textual)              
Preferred stock, shares outstanding             126
Series 5 Convertible Preferred Stock [Member]              
Capital Raises (Textual)              
Warrant exercise price per share after adjustment   $ 223.20          
Units sold in public offering   12,000          
Preferred stock, shares outstanding             126
Number of preferred shares sold under public offering   12,000          
Warrant [Member]              
Capital Raises (Textual)              
Purchase price per share       $ 9,558.00      
Warrants granted       334      
Gross proceeds from capital raise       $ 3,200      
Exercise price of warrants       $ 11,880.00      
Warrant exercise price per share after adjustment       $ 5,400.00      
Net proceeds from this offering       $ 2,800      
February Public Offering [Member]              
Capital Raises (Textual)              
Public offering, description     The Company completed a public offering for approximately $18 million in securities, consisting of an aggregate of 1,848 Class A units, at a price to the public of $4,230.00 per Class A unit, each consisting of one share of the Company's common stock and a five-year warrant to purchase one share of common stock at an exercise price of $6,300.00 per share ("February 2018 Warrants"), and 10,184.9752 Class B units, at a price to the public of $1,000 per Class B unit, each consisting of one share of the Company's newly designated Series 3 convertible preferred stock ("Series 3 Preferred") with a stated value of $1,000 and initially convertible into approximately 1 share of our common stock at a conversion price of $4,230.00 per share for up to an aggregate of 2,408 shares of common stock and February 2018 Warrants exercisable for the number of shares of common stock into which the shares of Series 3 Preferred were initially convertible.        
Net proceeds from this offering     $ 15,400        
Warrants to purchase shares of common stock after adjustment     24,055        
Gross proceeds from offering     $ 18        
Amounts payable to service providers     1        
Beneficial conversion feature value     $ 1,508        
Warrant exercise price after adjustment     $ 1,141.20        
April Public Offering [Member]              
Capital Raises (Textual)              
Public offering, description           Each consisting of (i) one share of our newly designated Series 4 convertible preferred stock (the "Series 4 Preferred") with a stated value of $1,000 and initially convertible into approximately 2 shares of common stock, at a conversion price of $828.00 per share (subject to adjustment) and (ii) one warrant to purchase such number of shares of common stock as each share of Series 4 Preferred is convertible into.  
Exercise price of warrants           $ 1,206.00  
Net proceeds from this offering           $ 9,200  
Public offering price, per unit           $ 1,000  
Gross proceeds from offering           $ 10,100  
Units sold in public offering           10,115  
Beneficial conversion feature value         $ 4,226 $ 673  
Deemed dividend           $ 4,899  
April Public Offering [Member] | Maximum [Member]              
Capital Raises (Textual)              
Preferred share conversion price         $ 828.00    
April Public Offering [Member] | Minimum [Member]              
Capital Raises (Textual)              
Preferred share conversion price         $ 320.40    
April Two Thousand Eighteen Capital Raise [Member]              
Capital Raises (Textual)              
Public offering, description           The conversion price of the Series 4 Preferred was reduced to the floor price of $223.20 and the exercise price of the warrants issued in the April offering were also reduced to the floor price of $223.20 and the number of shares issuable upon exercise of such warrants was increased to 61,562 shares of common stock.  
Warrants to purchase shares of common stock after adjustment           24,055  
Deemed dividend           $ 4,828  
Warrant exercise price after adjustment           $ 1,140.20